[WW] rewa - Long Covid

What is "Long Covid" (aka 'Long-haul Covid') ?

The contested meaning of “long COVID”
    – Patients, doctors, and the politics of subjective evidence
    ScienceDirect
    sciencedirect.com/science/article/pii/S0277953621009515
    [pub jan 2022]

What it is doing to your body


The new asbestosis or HIV/AIDS? “What if - and hear me out because this isn't crazy - Long Covid turns out to be the new asbestosis or HIV/AIDS? Something which starts off looking fairly benign, but brews up into something really nasty. (Though it isn't even starting off benign, TBH.)” Thread: Discussion. -- Dr David Berger @YouAreLObbyLud Twitter https://twitter.com/YouAreLobbyLud/status/1516212680989679616
1/ Let’s talk Long COVID: I’m grouping several important and interesting articles about the reality of Long Covid. By studying brain fluid, viral persistence and MRIs, we’re building our understanding of the “how” and “why” of this devastating malady.” Losts of images, infographics, and explanation. -- WesElyMD @WesElyMD Twitter https://twitter.com/WesElyMD/status/1501717860942553089 [pub 10 mar 2022]
new #LongCovid study — T cell death is worrisome "These observations describe an abnormal immune profile in patients with COVID19 at extended time points after infection & provide clear support for the existence of a syndrome of LongCovid" ➡️Please please avoid COVID!” -- Dr Eric Feigl-Ding @DrEricDing Twitter twitter.com/DrEricDing/status/1481722172695584772 [pub 14 jan 2022]
Mild respiratory SARS-CoV-2 infection can cause multi-lineage cellular dysregulation and myelin loss in the brain The study. “Not yet peer reviewed but from an outstanding team.” Biorxiv biorxiv.org/content/10.1101/2022.01.07.475453v1 [pub 7 jan 2022] | Mild respiratory SARS-CoV-2 infection can cause multi-lineage cellular dysregulation and myelin loss in the brain Twitter thread - good discussion. Link to study. Trisha Greenhalgh twitter.com/trishgreenhalgh/status/1480852877828579330 [pub 11 jan 2022]
SARS-CoV-2 infection and persistence throughout the human body and brain “Our data prove that SARS-CoV-2 causes systemic infection and can persist in the body for months.” Research Square researchsquare.com/article/rs-1139035/v1 [pub dec 2021]
How COVID-19 can damage the brain "Some people who become ill with the coronavirus develop neurological symptoms. Scientists are struggling to understand why." -- Michael Marshall Nature Nature.com/articles/d41586-020-02599-5 [pub 15 sep 2020]
Coronavirus may be a vascular disease, which explains everythingMedium elemental.medium.com/amp/p/2c4032481ab2

Articles and posts

Which Long Covid papers are the most important as ov feb 2022?
    "Of all the papers that have come out on LongCovid so far, which do you think are the most important? Particularly around biomedical findings? If you could let every doctor know 10 things (backed by published papers), what would they be?"
    Twitter thread - many links and infos.
    -- Hannah Davis  @ahandvanish
    Twitter thread.
    https://twitter.com/ahandvanish/status/1497376814951542788
    [pub 26 feb 2022]


SARS-COV-2 embedded in tissues "If there are SARS-COV-2 fragments/proteins in LongCovid sufferers tissues, then how is anyone meant to get them out?" Twitter thread - good and long discussion. -- Shaney Wright @ShaneyWright Twitter https://twitter.com/ShaneyWright/status/1496525069467725832 [pub 23 feb 2022]
No real tools to manage Long Covid "We hear a lot about all the tools we have to coexist with Covid. Well, I’ve had LongCovid for over 2 years now, and the only 'tools in my toolbox' available to manage it are the 3 B’s: Benadryl, Baby Aspirin, and a beta blocker. Before you risk repeated infections, think about this." Thread -- Laura Miers @LauraMiers Twitter https://twitter.com/LauraMiers/status/1495509173987119105 [pub 21 feb 2022]
Opinion: Long covid may unleash wave of health troubles after pandemic The Washington Post https://www.washingtonpost.com/opinions/2022/02/20/long-covid-may-unleash-health-troubles-after-pandemic/ [pub 20 feb 2022]
Understanding ME/CFS and Long COVID as post-viral conditions ME: Myalgic Encephalomyelitis CFS: Chronic Fatigue Syndrome Search at DuckDuckGo: https://duckduckgo.com/?q=ME+CFS+viral
The Forever Disease: How Covid-19 became a chronic condition The New Republic https://newrepublic.com/article/161102/covid-19-long-haulers-chronic-disease-health-care [pub feb 2022]
Covid reinfections lead to Long Covid "I hate making claims like this but I will: I believe reinfections can cause Long Covid, with its depleted subsets And sure, you can call that attrition." Thread on what is Long Covid "... repeated infection can put cells into a state of paralysis and even exhaustion." "Long covid is a state of persistent immune activation." "Many previously asymptomatic people would have no idea if they are on infection two, three or more." -- Anthony J Leonardi, PhD, MS @fitterhappierAJ Twitter thread - good and long discussion. Twitter https://twitter.com/fitterhappierAJ/status/1494770759285280771 [pub 19 feb 2022]
Antihistamines to treat long COVID: What you need to know Live Science Article. https://www.livescience.com/antihistamines-to-treat-long-covid-pasc [pub 17 feb 2022]
COVID-19 and mitochondrial non-coding RNAs: New insights from published data "This persistent alteration in the expression of small mitochondrial RNAs might be involved in the long COVID syndrome and further studies are needed to confirm the possibility." See the following Introduction section for a good summary of 'post-viral fatigue syndrome', which has been known for decades. -- Andrea Pozzi Physiology https://www.frontiersin.org/articles/10.3389/fphys.2021.805005/full [pub 4 feb 2022]
Long Covid, holy crap! Screenshots of entire article from NYTimes. https://imgur.com/gallery/hGv30in https://www.nytimes.com/interactive/2022/02/19/science/long-covid-causes.html [pub 19 feb 2022]
The risk of Long COVID "Long COVID is not a single ailment. It's a combination of a variety symptoms that cannot be explained in any other way but from a COVID infection. It can be caused by an acute infection, asymptomatic infection alone, or appear months after the infection. "Some folks who get it will never even know they had an infection." Lots of supported detail. -- Don Ford https://donford.substack.com/p/riskoflongcovid [pub feb 2022]
Nutritional support helps Long Covid Zinc, Vitamin D, Specific Probiotics: Lactiplantibacillus plantarum CBD oil… Have all held up under test. "a low-inflammation diet" "You need sun and to walk outside. You cannot fully supplement the natural Vitamin D your body creates as a natural steroid." [i don't know where i got this, have to find it - feb 2022]
Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection Study Nature https://www.nature.com/articles/s41590-021-01113-x [pub 13 jan 2022]
Exercise and MECFS “1/ The problem with Myalgic Encephalomyeltis/Chronic Fatigue Syndrome MECFS is that it seems so ridiculous that exercise could actually make patients worse How can exercise be so bad for pwME [people with ME] but so good for almost every other serious illness?” Twitter thread -- Dr Mark Guthridge @Dr_M_Guthridge Twitter https://twitter.com/Dr_M_Guthridge/status/1278308004845109249 [pub 1 jul 2020]
Long Covid missing from public messaging and government advice “All through this pandemic the fact of long term morbidity has been absent from public messaging and govt advice. @elizabethics is absolutely right - the public is ill informed and therefore can't be relied upon to make the right decisions.” -- @LongCovidSOS Twitter twitter.com/LongCovidSOS/status/1473821790296281089 [pub 23 dec 2021]
Don't be too cavalier about Omicron -- Long Covid is still a real risk "President Biden told the U.S. that if you’re triple vaxxed, you’re safe for the holidays. That’s not only not true, it’s dismissing almost 10 million Americans affected by a chronic disease." "... researchers behind a recent study published in the journal JAMA Network Open estimate that at least 50 percent of those who survive their initial illness go on to experience a number of physical, psychological, and neurological symptoms for a minimum of six months." -- Elizabeth Yuko Rolling Stone rollingstone.com/culture/culture-commentary/covid-omicron-long-covid-risk-1274717/ [pub 22 dec 2021]

How common is Long Covid?

Summary from what i have been reading: Some percentage of people who get a Covid infection, with or without symptoms, will live with symptoms anywhere from a few weeks, up to the number of years we have known Covid. I have read numbers from 10% to 50%. One of the reasons for this is that this Covid things is all new, and "Long Covid" is definitely new. So how it's measured will depend on different scientists' definitions.
— webwalker - feb 2022


10% chance of progressing to Long Covid “There's a 1 in 10 chance if you get Covid you'll suffer Long Covid. You may not be able to make the stairs in one go due to COPD type symptoms, children have lost motor skills, others parts of memory. Worse you'll have organ damage or blood clots leading to stroke. ” Thread with experiences and links. -- @TigressEllie Twitter twitter.com/TigressEllie/status/1477380948052295683 [pub 2 jan 2022]
Around 1 in 50 people in UK were reporting symptoms of Long Covid.” -- UK Office for National Statistics (ONS) ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/articles/coronaviruscovid19latestinsights/infections#long-covid [pub 16 dec 2021]
Long covid symptoms linger in 50 percent of people who survive the disease The Washington Post washingtonpost.com/health/long-covid-50-percent-lingering-symptoms/2021/11/12/e6655236-4313-11ec-9ea7-3eb2406a2e24_story.html [pub 12 nov 2021]

Experiences

Woman’s medical odyssey shows how the system fails long-haul patients
    The Washington Post
    https://www.washingtonpost.com/health/2022/04/18/long-covid-medical-care-challenge/
    [pub 18 apr 2022]

A deep-dive into Long Covid
    “We're launching a new mini-series this week, a deep-dive into Long Covid. 
    “Some people caught Covid in the first wave and simply never got better. Latest figures show 1.5million people in the UK now have Long Covid - and this could be the tip of the iceberg...”
    https://metro.co.uk/tag/long-covid/
    [pub 14 mar 2022]

Case of "mild Covid" turning into debilitating Long Covid
“Local surgeon — with decades of experience, in very high demand (>12-month waitlist), very physically fit (long-distance runner) — gets a mild case of Covid (never hospitalized), then abruptly retires due to persistent fatigue. Another face of "mild" Covid.”
    Thread of responses - many having post-viral fatigue after Covid. 
    twitter.com/DrHarryThomas/status/1481989232247951361
    [pub 14 jan 2022]

‘Your body just stops’
    long Covid sufferers face new ordeals as sick pay runs out
    The Guardian
    theguardian.com/world/2021/jun/24/your-body-just-stops-long-covid-sufferers-face-new-ordeals-as-sick-pay-runs-out
    [pub 23 jun 2021]

Long Covid, bad after-effects
    Comments and links 
    imgur.com/gallery/lUKSvNW
    [pub dec 2020]

More people's experiences living with Long Covid are on the rewa experiences page.

Collections of articles and info

Long Covid articles at Nature.com
    nature.com/search?q=long+covid&journal=
    [retr feb 2022]